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US 10,441,680 B2Granted
Placental tissue grafts produced by chemical dehydration/freeze-drying and methods for making and using the same
AssigneeMiMedx Group, Inc.
InventorsJohn Daniel, Randall Spencer, Steven Ray
Life of this patent
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Abstract
Described herein are placental tissue grafts produced by chemical dehydration followed by freeze-drying the placental tissue to produce the tissue graft. The tissue grafts retain their biological properties preferably at the same level as the placental tissues before they are processed. The placental tissue grafts have numerous medical applications. Methods for making the tissue graft compositions are also described herein.
Claims3
A laminated tissue graft comprising:
- a first membrane comprising modified decellularized amnion wherein the modified amnion comprises a first side and a second side, wherein the first side comprises an exposed basement membrane, and, and the second side is a decellularized fibroblast layer;
- a second membrane comprising a chorion membrane layered directly adjacent to the first membrane, wherein said chorion membrane is not decellularized;
- and
- optionally one or more additional membranes layered adjacent to the first or second membrane, wherein the one or more additional membranes is selected from the group consisting of amnion, chorion, Wharton's jelly, and combinations thereof.
1 more element
Dependencies are inferred from the claim text.