Joining and/or sealing tissues through photo-activated cross-linking of matrix proteins
AssigneeCook Medical Technologies LLC
InventorsAlan George Brownlee, Christopher Malcolm Elvin
Life of this patent
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Abstract
A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photoactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.
Claims22
A closure for a bleeding wound comprising:
- a substrate suitable for application to a wound to stem bleeding;
- and
- a liquid tissue adhesive carried by said substrate, said liquid tissue adhesive comprising a matrix protein, a photoactivatable metal-ligand complex, and an electron acceptor, wherein said matrix protein, said photoactivatable metal-ligand complex, and said electron acceptor are present in an amount effective to cause cross-linking reactions between said matrix protein to form a cross-linked protein matrix upon irradiation of said liquid tissue adhesive after implantation.
A light activated tissue adhesive wound dressing comprising:
- a light activated liquid absorbable medical adhesive, the liquid absorbable medical adhesive adherable to patient tissue so as to provide a hemostatic seal, the absorbable medical adhesive comprising:
- a matrix protein;
- a photoactivatable metal-ligand complex selected to absorb light in the visible region, said photoactivatable metal-ligand comprising a Ru(II), Pd(II), Cu(II), Ni(II), Mn(II), or Fe(III) complex;
- and
- an electron acceptor, and wherein said matrix protein, said photoactivatable metal-ligand complex, and said electron acceptor are present in an amount effective to form a cross-linked protein matrix comprising said matrix protein upon irradiation of said liquid absorbable medical adhesive.
A closure for a bleeding wound comprising:
- a substrate suitable for application to a bleeding wound;
- and
- a liquid tissue adhesive carried by said substrate, said liquid tissue adhesive comprising a matrix protein, a photoactivatable metal-ligand complex, and an electron acceptor, wherein said matrix protein, said photoactivatable metal-ligand complex, and said electron acceptor are present in an amount effective to cause cross-linking reactions between said matrix protein to form a cross-linked protein matrix upon irradiation of said liquid tissue adhesive after implantation, such that said closure is effective to provide a hemostatic seal over the bleeding wound.
Dependencies are inferred from the claim text.