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US 10,441,669 B2Granted
Multifunctional chelators, complexes, and compositions thereof, and methods of using same
AssigneeIllinois Institute of Technology
InventorHyun-Soon Chong
Life of this patent
Estimating the term…
Abstract
Multifunctional chelators, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.
Claims25
A compound of formula (I):
- where k is 0 or 1;
- m is 0 or 1;
- and each of Y1-Y4 independently is one of a structure of formula (a-1), (a-2), or (a-3):
- where p is 1 or 2;
- Z is hydrogen, formula (a-2), formula (a-3), Ar, a pyridylalkyl, a protecting group, an aryl containing group, an alkynyl containing group, an amine containing group, an azide containing group, or an amide containing group;
- Ar is or includes an aromatic ring or a heteroaromatic ring;
- and each R′ independently is OH, NH2, OR″, NR2″ wherein each R″ is one of alkyl, tert-butyl, allyl, benzyl, benzyloxy, or a protecting group;
- and
- wherein each of R1-18 independently is or includes hydrogen, carboxyalkyl, alkylamido, alkyl, allyl, benzyl, benzyloxyalkyl, cycloalkyl, alkoxy, hydroxyalkyl, aryl, aryloxy, hydroxyaryl, heteroaryl, phenyl, vinyl, alkynyl, alkenyl, furannylalkyl, alkylthioalkyl, arylhydroxyalkyl, indanyl, inolylalkyl, naphthylalkyl, imidazolylalkyl, pyridiylalkyl, benzothiophenylalkyl, thiophenylalkyl, thioalkyl, thioaryl, thiobenzyl, hydroxy, an alkynyl containing group, substituted carbonyl, hydroxyalkyl, triazolylalkyl, aminoalkyl, benzothiophenylalkyl, carboxyl, carboxyalkyloxy, amine, a protected amine, carboxylic acid, holoalkylamido, aldehyde, ester, amido, tosyl, phthalimidyl, maleimidyl, trityl, tert-butyloxycarbonyl, carbobenzyloxy, o-nosyl, acetyl, fluoroacetyl, dimethoxybenzyl, p-methoxybenzyl, an amide containing group, a thioamide containing group, an amino acid-containing group, an ester containing group, a protecting group, an amine protecting group or:
- where W is NH, oxygen, or sulfur, n is 1-5, and each of X1-X5 independently is or includes hydrogen, halo, cyano, alkyl, hydroxy, nitro, amino, alkylamino, thiocyano, isothiocyano, alkoxy, aryloxy, carboxyl, carboxyalkyl, carboxyalkyloxy, ester, amido, aldehydo, alkylamido, holoalkylamido, an ester containing group, an carbonyl containing group, an amide containing group, an amine containing group, a thioamide containing group, an alkynyl containing group, or an amino acid-containing group;
- wherein more than one of Y1-Y4 is formula (a-1);
- and
- wherein at least one of Y1-Y4 comprises:
- where X1 is described above or comprises NH2, NHBoc, NCS or NPhth.
11 more elements
A compound of formula (I):
- where k is 0 or 1;
- m is 0 or 1;
- and each of Y1-Y4 independently is one of a structure of formula (a-1), (a-2), or (a-3):
- where p is 1 or 2;
- Z is hydrogen, formula (a-2), formula (a-3), Ar, a pyridylalkyl, a protecting group, an aryl containing group, an alkynyl containing group, an amine containing group, an azide containing group, or an amide containing group;
- Ar is or includes an aromatic ring or a heteroaromatic ring;
- and each R′ independently is OH, NH2, OR″, NR2″ wherein each R″ is one of alkyl, tert-butyl, allyl, benzyl, benzyloxy, or a protecting group;
- wherein each of R1-18 independently is or includes hydrogen, carboxyalkyl, alkylamido, alkyl, allyl, benzyl, benzyloxyalkyl, cycloalkyl, alkoxy, hydroxyalkyl, aryl, aryloxy, hydroxyaryl, heteroaryl, phenyl, vinyl, alkynyl, alkenyl, furannylalkyl, alkylthioalkyl, arylhydroxyalkyl, indanyl, inolylalkyl, naphthylalkyl, imidazolylalkyl, pyridiylalkyl, benzothiophenylalkyl, thiophenylalkyl, thioalkyl, thioaryl, thiobenzyl, hydroxy, an alkynyl containing group, substituted carbonyl, hydroxyalkyl, triazolylalkyl, aminoalkyl, benzothiophenylalkyl, carboxyl, carboxyalkyloxy, amine, a protected amine, carboxylic acid, holoalkylamido, aldehyde, ester, amido, tosyl, phthalimidyl, maleimidyl, trityl, tert-butyloxycarbonyl, carbobenzyloxy, o-nosyl, acetyl, fluoroacetyl, dimethoxybenzyl, p-methoxybenzyl, an amide containing group, a thioamide containing group, an amino acid-containing group, an ester containing group, a protecting group, an amine protecting group or:
- where W is NH, oxygen, or sulfur, n is 1-5, and each of X1-X5 independently is or includes hydrogen, halo, cyano, alkyl, hydroxy, nitro, amino, alkylamino, thiocyano, isothiocyano, alkoxy, aryloxy, carboxyl, carboxyalkyl, carboxyalkyloxy, ester, amido, aldehydo, alkylamido, holoalkylamido, an ester containing group, an carbonyl containing group, an amide containing group, an amine containing group, a thioamide containing group, an alkynyl containing group, or an amino acid-containing group;
- wherein more than one of Y1-Y4 is formula (a-1);
- and
- wherein at least one Z comprises:
- where X1 is described above or comprises NH2, NHBoc, NCS or NPhth.
10 more elements
Dependencies are inferred from the claim text.