US 10,441,668 B2 · System and method for enhanced mass spectrometry imaging

Abstract

Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the tissue. The sample can then be provided to a high sensitivity analysis platform, such as a mass analyzer, to analyze the sample and determine a distribution of the exogenous agent or a by-product of the exogenous agent within the tissue based on the analysis. The analysis platform can then identify the region of interest based on the distribution of the exogenous agent or the distribution of the by-product.

Claims21

Dependent claims

A method of identifying a region of interest in tissue, the method comprising:

administering an exogenous agent to the tissue, the exogenous agent being capable of forming a by-product in the tissue;
analyzing a sample based on the tissue using a high sensitivity platform comprising a mass spectrometer;
determining a distribution, optionally quantitative, of the by-product of the exogenous agent within the tissue based on the analysis of the sample;
and
identifying the region of interest within the tissue based on the determined distribution of the by-product of the exogenous agent relative to tissue surrounding the region of interest.

2 more elements

A system for identifying a region of interest in tissue, the system comprising:

a sampling unit configured to acquire a sample based on the tissue after administration of an exogenous agent to the tissue, the exogenous agent being capable of forming a by-product in the tissue;
and
a high sensitivity platform comprising a mass spectrometer, the high sensitivity platform being coupled to the sampling unit to analyze the sample, the high sensitivity platform being configured to determine a distribution, optionally quantitative, of a by-product of the exogenous agent within the tissue based on a spectral analysis of the sample to determine spectral peaks due to the by-product of the exogenous agent that are not endogenous to the tissue and to identify the region of interest based on the determined distribution of the by-product of the exogenous agent relative to tissue surrounding the region of interest.

Dependencies are inferred from the claim text.

Facts

Application

15/533,799Filed 8 Dec 2015 · us provisional application

Priority

8 Dec 2014

Published

US 2017/0368205 A128 Dec 2017

Granted

15 Oct 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 49/106
The carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals: the complex-forming compound being…
A61K 49/00
Preparations for testing in vivo
A61K 49/0438
Containing an organic halogenated X-ray contrast-enhancing agent: organic X-ray contrast-enhancing agent comprising an iodinated group or an…
G01N 27/00
Investigating or analysing materials by the use of electric, electrochemical, or magnetic

System and method for enhanced mass spectrometry imaging

Life of this patent

System and method for enhanced mass spectrometry imaging

Life of this patent

Abstract

Claims21