Methods for treating cancer
AssigneeBicycleRD Limited
InventorsGavin Bennett, Daniel Paul Teufel
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of treating cancer in a subject.
Claims22
A method of treating cancer in a patient, wherein the cancer is selected from the group consisting of a sarcoma, lung cancer, breast cancer, colon cancer, gastric cancer, and head and neck cancer, comprising administering to said patient a therapeutically effective amount of BT1718, or a pharmaceutically acceptable salt and/or composition thereof,
- wherein
- the sarcoma is an N-ras mutant/IDH1 mutant soft tissue sarcoma (STS);
- the lung cancer is a Met-amplified squamous NSCLC, a Squamous cell NSCLC with wt EGFR, or a T790M EGFR-expressing lung adenocarcinoma;
- the breast cancer is a triple negative breast cancer;
- the colon cancer is a colorectal adenocarcinoma;
- the gastric cancer is a FGFR-amplified gastric cancer;
- and
- the head and neck cancer is a nasal septum squamous cell carcinoma,
- and wherein BT1718 is a Bicycle drug conjugate of formula:
A method of treating cancer in a patient, wherein the cancer is selected from the group consisting of a sarcoma, lung cancer, breast cancer, colon cancer, gastric cancer, and head and neck cancer, comprising administering to said patient a minimally effective dose of BT1718, or a pharmaceutically acceptable salt and/or composition thereof, wherein the minimally effective dose leads to tumor-stasis when administered intravenous twice a week (IV BIW),
- wherein
- the sarcoma is an N-ras mutant/IDH1 mutant soft tissue sarcoma (STS);
- the lung cancer is a Met-amplified squamous NSCLC, a Squamous cell NSCLC with wt EGFR, or a T790M EGFR-expressing lung adenocarcinoma;
- the breast cancer is a triple negative breast cancer;
- the colon cancer is a colorectal adenocarcinoma;
- the gastric cancer is a FGFR-amplified gastric cancer;
- and
- the head and neck cancer is a nasal septum squamous cell carcinoma,
- and wherein BT1718 is a Bicycle drug conjugate of formula:
Dependencies are inferred from the claim text.