Lipids for therapeutic agent delivery formulations
AssigneeNitto Denko Corporation
InventorsJoseph E. Payne, John A. Gaudette, Zheng Hou, Mohammad Ahmadian, Lei Yu, Victor Knopov, Violetta Akopian, Priya Karmali, Richard P. Witte, Neda Safarzadeh, Wenbin Ying, Jun Zhang
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Abstract
The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.
Claims22
A composition comprising lipid molecules comprising an ionizable lipid compound of formula I:
- wherein
- n and m are independently 1, 2, 3, or 4;
- R1 and R2 are independently C10-18alkyl-;
- X is —CH2—, wherein L is —OC1-4 alkylene- or
- —OC(O)C1-4 alkylene-;
- or
- X is absent, wherein L is —C1alkylene-, —C3alkylene-, —C4alkylene-, —OC1-4 alkylene-, or —OC(O)C1-4 alkylene-;
- or
- X is O or N, wherein L is —C1-4 alkylene-, or
- —C(O)C1-4 alkylene-;
- or a pharmaceutically acceptable salt form thereof;
- and a cationic lipid, wherein the cationic lipid is
A composition comprising a compound selected from the group consisting of
- or a pharmaceutically acceptable salt form thereof;
- and a cationic lipid, wherein the cationic lipid is
A composition comprising lipid molecules comprising an ionizable lipid compound of formula I:
- wherein
- n and m are independently 1, 2, 3, or 4;
- R1 and R2 are independently C10-18alkyl-;
- X is absent;
- L is —CH2CH2—;
- or a pharmaceutically acceptable salt form thereof;
- and a cationic lipid, wherein the cationic lipid is
A composition comprising lipid molecules comprising an ionizable lipid compound of formula I:
- wherein
- n and m are independently 2, 3, or 4;
- R1 and R2 are independently C12-18alkenyl-;
- X is absent;
- L is —CH2CH2—;
- or a pharmaceutically acceptable salt form thereof;
- and a cationic lipid, wherein the cationic lipid is
A composition comprising lipid molecules comprising an ionizable lipid compound of formula I:
- wherein
- n and m are independently 2, 3, or 4;
- R1 and R2 independently are a C12-18alkenyl-;
- X is —CH2—, wherein L is —OC1-4 alkylene or —OC(O)C1-4 alkylene-;
- or
- X is absent, wherein L is C1-C4alkylene, —OC1-4 alkylene, or
- —OC(O)C1-4 alkylene-;
- or
- X is O or N, wherein L is —C1-4 alkylene-, or
- —C(O)C1-4 alkylene-;
- or a pharmaceutically acceptable salt form thereof;
- and a cationic lipid, wherein the cationic lipid is
A composition comprising lipid molecules comprising an ionizable lipid compound of formula I:
- wherein
- n and m are 1;
- R1 and R2 independently are a C12-18alkenyl;
- X is —CH2—, wherein L is —OC1-4 alkylene- or —OC(O)C1-4 alkylene-;
- or
- X is absent, wherein L is —C1-4alkylene-, —OC1-4 alkylene-, or —OC(O)C1-4 alkylene-;
- or
- X is O or N, wherein L is —C1-4 alkylene-, or
- —C(O)C1-4 alkylene-;
- or a pharmaceutically acceptable salt form thereof;
- and a cationic lipid, wherein the cationic lipid is
Dependencies are inferred from the claim text.