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US 10,441,658 B2Granted
Ophthalmic composition
AssigneeJohnson & Johnson Consumer Inc.
InventorsMingqi Bai, Kenneth T. Holeva
Life of this patent
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Abstract
The present invention relates to ophthalmic compositions for treatment of conditions in the eye. More specifically, the present invention relates to ophthalmic compositions comprising a polyquaternium compound and an anionic polymer. Methods for reducing and/or preventing the incompatibility of polyquaternium compounds with anionic polymers are also disclosed.
Claims1
A method of reducing the precipitation of a polyquaternium compound and an anionic polymer in a composition ophthalmologically suitable for application to the eyes comprising such compounds, comprising the steps of:
- i) providing from about 0.001% to about 0.5% of an anionic polymer having a weight average molecular weight of from about 250 to about 4,000,000 Daltons;
- ii) adding an effective amount of an organic acid, salts thereof or mixtures thereof, such that the organic acid binds with the monomer units of the polyquaternium compound at at least a 1:1 molar ratio;
- and
- iii) adding from about 10 ppm to about 1000 ppm of a polyquaternium compound having a weight average molecular weight of from about 150 to about 15,000 Daltons;
- wherein the composition is substantially free of cationic oligomer compounds and precipitation inhibiting compounds.
2 more elements
Dependencies are inferred from the claim text.