Nanoparticle complexes of paclitaxel, cetuximab, and albumin, and methods of making the same
AssigneeMayo Foundation for Medical Education and Research
InventorsSvetomir N. Markovic, Wendy K. Nevala
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Abstract
This invention relates to methods of making antibody-albumin nanoparticle complexes and pharmaceutical compositions thereof, comprising albumin, an antibody with binding specificity for a EGFR cetuximab), and paclitaxel, the methods comprising mixing in vitro an aqueous albumin-paclitaxel nanoparticle with an antibody with binding specificity for EGFR cetuximab) under conditions to form the nanoparticle complexes.
Claims15
A method of making an antibody-albumin nanoparticle complex, the method comprising mixing in vitro an aqueous albumin-paclitaxel nanoparticle with an antibody with binding specificity for epidermal growth factor receptor (EGFR) under conditions to form the nanoparticle complex, wherein the antibody is cetuximab, and wherein said nanoparticle complexes have an average diameter of between 0.1 μm and 1 μm.
A method of making a pharmaceutical composition comprising a pharmaceutically acceptable carrier and antibody-albumin nanoparticle complexes, the method comprising mixing aqueous albumin-paclitaxel nanoparticles with an antibody with binding specificity for epidermal growth factor receptor (EGFR) in vitro under conditions to firm the nanoparticle complexes, and adding the pharmaceutically acceptable carrier to the nanoparticle complexes, wherein the antibody is cetuximab, and wherein said nanoparticle complexes have an average diameter of between 0.1 μm and 1 μm.
Dependencies are inferred from the claim text.