Compositions and methods for the treatment or prevention of hepatitis B virus infection
AssigneeGlobeImmune, Inc.
InventorsDavid Apelian, Thomas H. King, Zhimin Guo, Claire Coeshott
Life of this patent
Estimating the term…
Abstract
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
Claims21
An immunotherapeutic composition comprising:
- a) a yeast vehicle;
- and
- b) a fusion protein comprising HBV antigens, wherein the HBV antigens consist of:
- a) an HBV surface antigen consisting of at least one immunogenic domain of hepatocyte receptor region of Pre-S1 of the HBV large surface antigen (L) and at least one immunogenic domain of HBV small surface antigen (S);
- b) an HBV polymerase antigen consisting of at least one immunogenic domain of reverse transcriptase domain of HBV polymerase;
- c) an HBV core antigen consisting of at least one immunogenic domain of HBV core protein;
- and
- d) an HBV X antigen consisting of at least one immunogenic domain of full-length HBV X antigen;
- and wherein the HBV antigens consist of an amino acid sequence that is at least 95% identical to positions 92 to 1025 of SEQ ID NO:92, wherein the composition elicits an HBV-specific immune response and wherein the fusion protein is expressed by the yeast vehicle.
A yeast expressing a fusion protein comprising HBV antigens, wherein the HBV antigens consist of:
- a) an HBV surface antigen consisting of at least one immunogenic domain of hepatocyte receptor region of Pre-S1 of the HBV large surface antigen (L) and at least one immunogenic domain of HBV small surface antigen (S);
- b) an HBV polymerase antigen consisting of at least one immunogenic domain of reverse transcriptase domain of HBV polymerase;
- c) an HBV core antigen consisting of at least one immunogenic domain of HBV core protein;
- d) an HBV X antigen consisting of at least one immunogenic domain of full-length HBV X antigen;
- and
- wherein the HBV antigens consist of an amino acid sequence that is at least 95% identical to positions 92 to 1025 of SEQ ID NO:92.
A fusion protein comprising HBV antigens, wherein the HBV antigens consist of:
- a) an HBV surface antigen consisting of at least one immunogenic domain of hepatocyte receptor region of Pre-S1 of the HBV large surface antigen (L) and at least one immunogenic domain of HBV small surface antigen (S);
- b) an HBV polymerase antigen consisting of at least one immunogenic domain of reverse transcriptase domain of HBV polymerase;
- c) an HBV core antigen consisting of at least one immunogenic domain of HBV core protein;
- d) an HBV X antigen consisting of at least one immunogenic domain of full-length HBV X antigen;
- and
- wherein the HBV antigens consist of an amino acid sequence that is at least 95% identical to positions 92 to 1025 of SEQ ID NO:92.
Dependencies are inferred from the claim text.