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AssigneesMayo Foundation for Medical Education and Research, University of Leeds
InventorsJose S. Pulido, Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Rosa Maria Diaz, Christine Marie Pulido, Alan A. Melcher, Peter Selby
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This document provides methods and materials for treating cancer. For example, methods and materials for treating cancer using combinations of antigens are provided. For example, VSV vectors designed to express a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen can be used to reduce the number of cancer cells (e.g., uveal melanoma cells) within a mammal (e.g., a human). In some cases, VSV vectors designed to express a BRAF antigen, a TOPO-11a antigen, and a YB-I antigen can be used to reduce the number of cancer cells (e.g., skin melanoma cells) within a mammal (e.g., a human). The composition can comprise less than 50 separate nucleic acid molecules.
A composition comprising one or more viral vectors comprising nucleic acid, wherein the nucleic acid of said composition encodes a combination of tumor antigens, wherein said combination of tumor antigens consists of a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen, and wherein said GNAQ antigen, said TYRP1 antigen, and said N-RAS antigen are expressed from said viral vectors.
A method of treating cancer within a mammal, wherein said method comprises administering to said mammal a composition comprising one or more viral vectors comprising nucleic acid, wherein the nucleic acid of said composition encodes a combination of tumor antigens, wherein said combination of tumor antigens consists of a GNAQ antigen, a TYRP1 antigen, and an N-RAS antigen, and wherein said GNAQ antigen, said TYRP1 antigen, and said N-RAS antigen are expressed from said viral vectors.
Dependencies are inferred from the claim text.