Application of dipeptide as ace enzyme activity inhibitor
AssigneeWithyou Biotechnology Co., Ltd.
InventorsXionglei He, Wei Zhu
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Abstract
An application of dipeptide as an ACE enzyme activity inhibitor. Virtual screening is performed on 400 types of dipeptide based on ACE inhibiting effects thereof according to a detected ACE enzyme crystal structure by using self-developed software and adopting a molecular docking method, experiments are conducted to verify the ACE inhibitory activity of the dipeptide obtained by virtual screening, and it finds out that the dipeptide with the N terminal as cysteine has better ACE inhibitory activity.
Claims2
A method of inhibiting an ACE enzyme by exposing the ACE enzyme to an ACE enzyme activity inhibitor, wherein the ACE enzyme activity inhibitor is a dipeptide, wherein said dipeptide is selected from the group consisting of CA, CH, CI, or CK;
- the N-terminal of the dipeptide is a cysteine, the amino acid in the dipeptide is in L-form or D-form, and at least one amino acid in the dipeptide is optionally modified with a group which can improve the stability of the dipeptide in vivo;
- wherein the C-terminal amino acid of the dipeptide is a basic amino acid or an aliphatic amino acid;
- wherein the basic amino acid is H or K;
- and
- wherein the aliphatic amino acid is A or I.
Dependencies are inferred from the claim text.