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AssigneeAjou University Industry-Academic Cooperation Foundation
InventorsSang Myun Park, Jung Sub Park, Yun Hoon Choung, Yeon Ju Kim
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The present invention provides a compound having an effect of preventing and/or treating the damage or degeneration of cochlear (and vestibular) mother cells and spiral ganglion neurons by downregulating a cysteinyl leukotriene receptor. Particularly, the present invention provides a composition for preventing or treating sensorineural hearing loss, containing a cysteinyl leukotriene receptor and a Ginkgo biloba extract as active ingredients, on the basis of the co-administration of a cysteinyl leukotriene receptor and a Ginkgo biloba extract having an excellent effect of protecting hearing.
A method of treating sensorineural hearing loss caused by damage to hair cells in an inner ear and surrounding tissue thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a compound of Chemical Formula 1:
A method of improving sensorineural hearing loss caused by damage to hair cells in an inner ear and surrounding tissue thereof, comprising administering to a subject in need thereof an effective amount of a food composition comprising a compound of Chemical Formula 1:
A method of treating sensorineural hearing loss caused by damage to hair cells in an inner ear and surrounding tissue thereof, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising (a) a compound of Chemical Formula 1, and (b) a Ginkgo biloba extract:
A method of improving sensorineural hearing loss caused by damage to hair cells in an inner ear and surrounding tissue thereof, comprising administering to a subject in need thereof an effective amount of a food composition comprising (a) a compound of Chemical Formula 1, and (b) a Ginkgo biloba extract:
Dependencies are inferred from the claim text.