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US 10,441,607 B1Granted
Multifunctional linker technology containing an N4 group
AssigneeBoard of Regents, The University of Texas System
InventorsAli Azhdarinia, Sukhen C. Ghosh, Nathaniel L. Wilganowski, Eva M. Sevick-Muraca
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Abstract
In some aspects, the present disclosure provides compositions comprising an N4-based MMC ligand, a cell targeting group, and a fluorophore or a therapeutic compound comprising a formula: wherein the variables are as defined herein. In some embodiments, these compositions may be used in the imaging techniques or in the treatment of a disease or disorder such as cancer.
Claims17
A compound of the formula:
- wherein:
- two of R1, R2, R3, and R4 are -A-COR5, wherein:
- A is alkanediyl(C≤8) or substituted alkanediyl(C≤8);
- and
- R5 is hydroxy, alkoxy(C≤8), or substituted alkoxy(C≤8);
- one of R1, R2, R3, or R4 is a peptide group, wherein the peptide group comprises a conjugated antibody that comprises a light and heavy variable region;
- one of R1, R2, R3, and R4 is a fluorophore group or
- a chemotherapeutic group;
- and
- M is a metal atom of any oxidation state or absent;
- or a pharmaceutically acceptable salt thereof, wherein:
- R5 is alkoxy(C≤8);
- or
- R4 is a chemotherapeutic group.
11 more elements
Dependencies are inferred from the claim text.