Back to results
US 10,441,606 B2Granted
Polymers for reversing heparin-based anticoagulation
AssigneeThe University of British Columbia
InventorsJayachandran N. Kizhakkedathu, Rajesh A. Shenoi, Cedric J. Carter, Donald E. Brooks
Life of this patent
Estimating the term…
Abstract
Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.
Claims9
A method of counteracting heparin in a subject, the method comprising:
- administering a heparin binding polymer to the subject, wherein the heparin binding polymer comprises:
- a core unit, wherein the core unit comprises a C1-18 alkyl substituted with three or more of —OR1,
- wherein each R1 is independently selected from a polymer segment having monomer units of Formula (III):
- wherein n is an integer from 1 to 10,000;
- wherein each R2 is independently selected from a hydrogen, carbon, a cationic moiety, R1, and a polymer segment of Formula (IV):
- wherein each R3 is independently selected from an oxygen cationic moiety, a hydroxyl, and a polymer segment of Formula (IV),
- wherein m is an integer from 1 to 10,000
- wherein each R4 is independently selected from a C1-6 alkoxy,
- wherein the heparin binding polymer comprises 16 to 25 cationic moieties, wherein the cationic moieties have a positive charge when the heparin binding polymer is at a physiological pH,
- wherein the cationic moieties are of Formula (VI):
- and wherein the molecular weight of the heparin binding polymer is about 20 kDa to 25 kDa.
8 more elements
A method of counteracting heparin in a subject, the method comprising:
- administering a heparin binding polymer to the subject, wherein the heparin binding polymer comprises:
- a core unit, wherein the core unit comprises a C1-18 alkyl substituted with three or more of —OR1,
- wherein each R1 is independently selected from a polymer segment having monomer units of Formula (III):
- wherein n is an integer from 1 to 10,000;
- wherein each R2 is independently selected from a hydrogen, carbon, a cationic moiety, R1, and a polymer segment of Formula (IV):
- wherein each R3 is independently selected from an oxygen cationic moiety, a hydroxyl, and a polymer segment of Formula (IV),
- wherein m is an integer from 1 to 10,000
- wherein each R4 is independently selected from a C1-6 alkoxy,
- wherein the heparin binding polymer comprises 4 to 24 cationic moieties, wherein the cationic moieties have a positive charge when the heparin binding polymer is at a physiological pH,
- wherein the cationic moieties are of Formula (VI):
- and wherein the molecular weight of the heparin binding polymer is about 20 kDa to 25 kDa.
8 more elements
Dependencies are inferred from the claim text.