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US 10,441,596 B2Granted
Methods and compositions related to glucocorticoid receptor antagonists and breast cancer
AssigneeThe University of Chicago
InventorsDeng Pan, Masha Kocherginsky, Suzanne D. Conzen
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Abstract
Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.
Claims20
A method for treating estrogen receptor alpha-negative breast cancer in a patient, the method comprising:
- determining that the breast cancer does not express detectable levels of estrogen receptor alpha;
- and a) administering radiation or at least a first chemotherapeutic agent to said patient;
- then b) administering an effective amount of a glucocorticoid receptor antagonist (GRA) to the patient;
- then c) administering radiation again or at least a second chemotherapeutic agent to the patient after the glucocorticoid receptor antagonist is administered to the patient, whereby said estrogen receptor alpha-negative breast cancer is treated in the patient.
1 more element
Dependencies are inferred from the claim text.