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US 10,441,588 B2Granted
Methods and compositions for treating bacterial infection
AssigneesThe Curators of the University of Missouri, Nanova, Inc.
InventorsHongmin Sun, David W. Anderson, Feng Qi
Life of this patent
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Abstract
The present disclosure relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present disclosure provides compounds as therapeutic agents against bacterial infections (e.g., biofilms). The present disclosure also provides topical formulations for use in methods for treating bacterial infections.
Claims8
A topical formulation for treating a bacterial infection comprising:
- a compound having the structure of Formula V
- wherein X is SR1, NH2, NHR1, NR1R, OH, OR1, or Cl;
- wherein R and R1 are, independently, H, a C1-C8 alkyl or alkenyl or cycloalkyl, optionally substituted with F, CN, OR6, NR62, COR6, CO2R6, CONHR6, aryl or heteroaryl, wherein one or more alkyl carbons may be replaced by O;
- R2 is H or a Cl alkyl;
- R3 and R4 are, independently, a C1-C8 alkyl;
- R5 is C1-C6 alkyl, CN, OR6, NR62, COR6, CO2R6, CONHR6, aryl, heteroaryl, SO2R6, NHCOR6, SO2NHR6, or OCOR6;
- R6 is H, C1-C6 alkyl, C0-C3 alkyl-aryl, or C0-C3 alkyl-heteroaryl, all optionally substituted;
- and R11 is H or a C1 alkyl;
- and
- a base comprising a hydrocarbon base, an oil, and combinations thereof.
7 more elements
A topical formulation for treating a bacterial infection comprising:
- a compound having the structure of Formula V
- wherein X is SR1, NH2, NHR1, NR1R, OH, OR1, or Cl;
- wherein R, R1 and R2 are, independently, H, a C1-C8 alkyl or alkenyl or cycloalkyl, optionally substituted with F, CN, OR6, NR62, COR6, CO2R6, CONHR6, aryl or heteroaryl, wherein one or more alkyl carbons may be replaced by O;
- R3 and R4 are, independently, a C1-C8 alkyl;
- R5 is H, C1-C6 alkyl, CN, OR6, NR62, COR6, CO2R6, CONHR6, aryl, heteroaryl, SO2R6, NHCOR6, SO2NHR6, or OCOR6;
- R6 is H, C1-C6 alkyl, C0-C3 alkyl-aryl, or C0-C3 alkyl-heteroaryl, all optionally substituted;
- and R11 is H or a Cl alkyl;
- and
- a base comprising a vegetable oil,
- wherein the formulation is a topical formulation.
7 more elements
Dependencies are inferred from the claim text.