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US 10,441,587 B2Granted
Treatment of lung cancer with inhibitors of glutaminase
AssigneeCalithera Biosciences, Inc.
InventorsFrancesco Parlati, Melissa G. Works, Mirna L. M. Rodriguez, Dong Zhang
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Abstract
The invention relates to methods of treating lung cancer using glutaminase inhibitors. In particular, results demonstrate that lung cancers characterized by an EGFR or KRAS mutation are treated by glutaminase inhibitors.
Claims12
A method for therapeutically treating lung cancer in a patient, the method comprising:
- a) determining whether the lung cancer is characterized by a KRAS mutation or EGFR mutation;
- and
- b) if the lung cancer is characterized by a KRAS mutation or EGFR mutation, then administering to the patient an effective amount of a compound of Formula III:
- or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.