CRMP2 SUMOylation inhibitors and uses thereof
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMay Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla
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Abstract
The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
Claims2
A compound encompassed within the following formula:
- wherein X is either NH or O;
- wherein R1 is selected from the group consisting of
- selected from the group consisting of:
- wherein R2 is selected from the group consisting of hydrogen, OCH3, and Flourine;
- wherein R3 is selected from the group consisting of
Dependencies are inferred from the claim text.