Treatment for wolfram syndrome and other endoplasmic reticulum stress disorders
AssigneeWashington University
InventorsFumihiko Urano, Simin Lu
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Abstract
The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.
Claims20
A method of treating Wolfram Syndrome in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a ryanodine receptor inhibitor, wherein the ryanodine receptor inhibitor comprises azumolene or a pharmaceutically acceptable salt or hydrate thereof.
A method of treating Wolfram Syndrome in a human subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising dantrolene or a pharmaceutically acceptable salt or hydrate thereof, wherein the human subject has an age that is 16 years or less.
A method of treating Wolfram Syndrome in a human subject in need thereof consisting of administering to the subject a therapeutically effective amount of a composition consisting of dantrolene or a pharmaceutically acceptable salt or hydrate thereof and one or more pharmaceutically acceptable carriers.
A method of treating Wolfram Syndrome in a human subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising dantrolene or a pharmaceutically acceptable salt or hydrate thereof, wherein the subject does not have Type 1 or Type 2 diabetes.
Dependencies are inferred from the claim text.