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US 10,441,573 B2Granted
DBH inhibitors for treating memory loss
AssigneeBrandeis University
InventorJohn Lisman
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Abstract
The present invention relates to the use of DBH inhibitors (e.g., disulfiram and Nepicastat), and pharmaceutical compositions thereof, for treating subjects with certain types of memory loss, for instance memory loss associated with a neurodegenerative disease, disorder, or condition, such as Alzheimer's Disease.
Claims20
A method comprising steps of:
- administering to a subject suffering from or susceptible to memory loss associated with a neurodegenerative disease, disorder, or conditioner (i) an effective amount of a DBH inhibitor, and (ii) one or more agents that ameliorate noradrenaline reduction associated with use of a DBH inhibitor, such that the severity or incidence of memory loss is reduced, or its onset is delayed.
A method comprising steps of:
- administering to a subject suffering from or susceptible to memory loss associated with degeneration of the locus coeruleus (LC) (i) an effective amount of a DBH inhibitor, and (ii) one or more agents that ameliorate noradrenaline reduction associated with use of a DBH inhibitor, such that the severity or incidence of memory loss is reduced, or its onset is delayed.
Dependencies are inferred from the claim text.