Self-emulsifying formulations of DIM-related indoles
AssigneeBioResponse, L.L.C.
InventorsMichael A. Zeligs, Irwin C. Jacobs
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Abstract
Disclosed herein are self-emulsifying compositions and formulations of Diindolylmethane (“DIM”) and certain derivatives of DIM, their uses and methods of making. In particular, the disclosed compositions comprise a DIM-related indole as an active agent and a carrier, wherein the carrier comprises a solvent, one or more surfactants with an HLB of greater than 7, and one or more co-surfactants with an HLB equal to or less than 7. In certain aspects of the invention, the compositions disclosed herein show improved bioavailability.
Claims28
A composition comprising 3,3′-diindolylmethane (“DIM”) as the biologically active agent and a carrier of said active agent, wherein the carrier comprises:
- (i) an essential oil, wherein the essential oil is peppermint oil, tea tree oil, wintergreen oil, lemon oil, lime oil, lavender oil, ginger oil, nutmeg oil, fennel oil, eucalyptus oil, rosemary oil, pomegranate seed oil, black cumin oil, clove oil, mustard oil, or cinnamon bark oil,
- (ii) a lauroyl polyoxyl-32 glyceride,
- (iii) propylene glycol caprylate,
- (iv) polysorbate 80 or tocopherol PEG 1000 succinate, and
- (v) a lecithin;
- wherein the composition, upon dispersion in water or contact with gastrointestinal fluids, emulsifies to form a dispersion of oil-in-water globules.
Dependencies are inferred from the claim text.