Use of butylidenephthalide
AssigneeEverfront Biotech Inc.
InventorsHorng-Jyh Harn, Shinn-Zong Lin
Life of this patent
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Abstract
Disclosed is the use of an active ingredient in the manufacture of a medicament, wherein the active ingredient is selected from the group consisting of butylidenephthalide (BP), a pharmaceutically acceptable salt of butylidenephthalide, and combinations thereof, and wherein the medicament is used for the prevention and/or treatment of oral submucous fibrosis (OSF) and may be used in the form of an injection lozenge, oral solution, or smearing preparation.
Claims4
A method for treating oral submucous fibrosis (OSF), comprising administering to a subject in need an effective amount of an active ingredient, wherein the active ingredient is selected from the group consisting of butylidenephthalide (BP), a pharmaceutically acceptable salt of butylidenephthalide, and combinations thereof.
A method for treating oral submucous fibrosis (OSF), comprising administering to a subject in need an effective amount of an active ingredient, wherein the active ingredient is selected from the group consisting of butylidenephthalide (BP), a pharmaceutically acceptable salt of butylidenephthalide, and combinations thereof, wherein the method is for at least one of inhibiting epithelial-mesenchymal transition (EMT) of oral submucosal tissue cells, inhibiting the abilities of oral submucosal tissue cells to crawl and invade, inhibiting oral submucosal tissue cells to differentiate into myofibroblasts, inhibiting the activation of myofibroblasts, and inhibiting the contraction of extracellular matrix in oral submucosal tissues.
Dependencies are inferred from the claim text.