Conjugate of memantine and arctigenin, and composition and use thereof

A conjugate comprising a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, polymorph, or solvate thereof:

• wherein:
• Linker 1 is selected from the group consisting of —C(O)—, —C(O)L1C(O)—, —C(O)OL1C(O)—, —C(O)OL1OC(O)—, —C(O)OQ1L2Q2-, —C(O)Q1L2Q2N(R1)C(O)—, —C(O)Q1L2Q2OC(O)—, —C(O)Q1L2Q2C(O)—, —C(O)OQ1L2Q2OC(O)—, —C(O)OQ1L1Q2N(R1)C(O)—, —C(O)OQ1L2Q2N(R1)C(O)— and —C(O)OQ1L2Q2C(O)—;
• L1 is a direct bond, or is selected from the group consisting of —O—, —S—, —NR2—, substituted or unsubstituted C1-C6 straight or branched alkylene, substituted or unsubstituted C2-C6 straight or branched alkenylene, substituted or unsubstituted C2-C6 straight or branched alkynylene, substituted or unsubstituted C3-C10 cyclrejectionlkylene, substituted or unsubstituted C3-C10 non-aromatic heterocyclylene, substituted or unsubstituted C6-C14 arylene, substituted or unsubstituted C6-C14 heterrectionrylene, and substituted or unsubstituted C6-C20 aralkylene;
• L2 is a direct bond, or is selected from the group consisting of —NR2—, —O—, —C(O)—, —N(R3)C(O)—, —C(O)N(R3)—, —C(O)O—, —OC(O)—, —N(R3)Q3O—, —N(R3)C(O)Q3O—, —N(R3)C(O)Q3C(O)—, —N(R3)C(O)Q3N(R3)—, —N(R3)C(O)Q3C(O)N(R3)—, —N(R3)C(O)Q3N(R3)C(O)—, —N(R3)C(O)Q3C(O)O—, —N(R3)C(O)Q3OC(O)—, —C(O)N(R3)Q3C(O)N(R3)—, —C(O)N(R3)Q3C(O)O—, —C(O)N(R3)Q3N(R3)C(O)—, —C(O)N(R3)Q3OC(O)—, —N(R3)Q3C(O)N(R3)—, —N(R3)Q3C(O)O—, —N(R3)Q3N(R3)C(O)—, —N(R3)Q3OC(O)—, —OQ3N(R3)—, —OQ3C(O)N(R3)—, —OQ3C(O)O—, —OQ3N(R3)C(O)—, —OQ3OC(O)—, —OC(O)Q3-, —OC(O)Q3C(O)N(R3)—, —OC(O)Q3C(O)O—, —OC(O)Q3N(R3)—, —OC(O)Q3N(R3)C(O)—, —OC(O)Q3N(R3)L1O—, —OC(O)Q3OC(O)—, —C(O)OQ3-, —C(O)OQ3O—, —C(O)OQ3C(O)N(R3)—, —C(O)OQ3C(O)O—, —C(O)OQ3N(R3)C(O)— or —C(O)OQ3OC(O)—;
• Q1, Q2 and Q3 are each independently selected from the group consisting of substituted or unsubstituted C1-C6 straight or branched alkylene, substituted or unsubstituted C3-C10 cyclrejectionlkylene, substituted or unsubstituted C2-C6 straight or branched alkenylene, substituted or unsubstituted C2-C6 straight or branched alkynylene, substituted or unsubstituted C3-C10 non-aromatic heterocyclylene, substituted or unsubstituted C6-C14 arylene, substituted or unsubstituted C6-C14 heterrejectionrylene, and substituted or unsubstituted C6-C20 aralkylene;
• and
• R1, R2 and R3 are each independently selected from the group consisting of H and C1-C6 alkyl.