A19-144, A2-73 and certain anticholinesterase inhibitor compositions and method for anti-seizure therapy
AssigneeAnavex Life Sciences Corp.
InventorsMissling U. Christopher, Durrant Cameron
Life of this patent
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Abstract
This invention concerns a dosage form comprising a therapeutically effective amount of A19-144 or A2-73 and a therapeutically effective amount of at least one AED. This invention further encompasses a method of treating a subject in need of such treatment comprising administering a therapeutically effective amount of A19-144 or A2-73 in conjunction with an therapeutically effective amount of an AED.
Claims6
A dosage form comprising a therapeutically effective amount of an anti-seizure drug selected from A19-144 and a combination of A19-144 and A2-73, and a sub-MED amount of at least one anti-epilepsy drug (AED), wherein the sub-MED dose and the at least one AED are selected from the group consisting of:
- less than about 8 mg/day of acetazolamide;
- less than about 1.5 mg/day of Clonazepam for an adult, less than about 0.01 mg/kg/day of Clonezepam for a child up to 10 years of age or 30 kg of body weight;
- less than about 30 (mg) of Clorazepate;
- less than about 0.1 mg/kg of Lorazepam;
- less than about 0.2 mg/kg of Midazolam;
- less than about 7.5 mg/day of Carbamazepine;
- less than about 0.2 mg/kg of Diazepam;
- less than about 30 mg/day of Chlordiazepoxide;
- less than about 5 mg/day for body weight 30 kg or less, and less than about 10 mg/day for body weight 30 kg or more, of Clobazam;
- less than about 5 mg/kg/day of Hydrocortisone;
- less than about 800 mg/day of Eslicarbazepine/Eslicarbazepine acetate;
- less than about 250 mg daily every 4-7 days of Ethosuximide;
- less than about 2 g daily of Ethotoin;
- less than about 1200 mg/day for adults, for children 2-14 yrs, less than about 15 mg/kg/day of Felbamate;
- less than about 50 mg twice daily of Lacosamide;
- less than about 25 mg/day of Lamotrigine;
- less than about 1000 mg/day of Levetiracetam;
- less than about 200 mg/day of Mephyntoin;
- less than about 400 mg/day of Mephobarbitol;
- less than about 250 mg daily every 4-7 days of Methsuxamide;
- less than about 600 mg/day of Oxcarbazepine;
- less than about 150 mg/day of Paramethadione;
- less than about 2 mg/day of Perampanel (Fycompa);
- less than about 500 milligrams three times a day of Phenacemide;
- establish a serum level of less than about 10 μg/mL of Phenobarbital;
- less than about 0.5 g b.i.d of Phensuxamide;
- less than about 100 mg a day of Phenytoin;
- less than about 75 mg 2 times a day of Pregabalin;
- a dose of less than about 10 mg/kg/day of Primidone;
- daily dose of less than about 2100 mg of Progabide;
- less than about 400 mg/day of Rufinamide;
- less than about 250 mg twice a day of Stiripentol;
- less than about 100 mg/day of Sulthiame;
- less than about 4 mg/day of Tiagabine;
- less than about 25 mg/day of Topiramate;
- less than about 900 mg/day of Tremethadione;
- less than about 10 mg/kg of Valproate;
- less than about 50 mg/kg/day of Vigabatrin and, less than about 100 mg once a day of Zonisamide.
A method of treating seizures in a subject in need of such treatment comprising administering an therapeutically effective amount of A19-144 or a combination of A19-144 and A2-73 in conjunction with a sub-MED amount of an AED, wherein the sub-MED dose and the at least one AED are selected from the group consisting of:
- less than about 8 mg/day of acetazolamide;
- less than about 1.5 mg/day of Clonazepam for an adult, less than about 0.01 mg/kg/day of Clonezepam for a child up to 10 years of age or 30 kg of body weight;
- less than about 30 (mg) of Clorazepate;
- less than about 0.1 mg/kg of Lorazepam;
- less than about 0.2 mg/kg of Midazolam;
- less than about 7.5 mg/day of Carbamazepine;
- less than about 0.2 mg/kg of Diazepam;
- less than about 30 mg/day of Chlordiazepoxide;
- less than about 5 mg/day for body weight 30 kg or less, and less than about 10 mg/day for body weight 30 kg or more, of Clobazam;
- less than about 5 mg/kg/day of Hydrocortisone;
- less than about 800 mg/day of Eslicarbazepine/Eslicarbazepine acetate;
- less than about 250 mg daily every 4-7 days of Ethosuximide;
- less than about 2 g daily of Ethotoin;
- less than about 1200 mg/day for adults, for children 2-14 yrs, less than about 15mg/kg/day of Felbamate;
- less than about 50 mg twice daily of Lacosamide;
- less than about 25 mg/day of Lamotrigine;
- less than about 1000 mg/day of Levetiracetam;
- less than about 200 mg/day of Mephyntoin;
- less than about 400 mg/day of Mephobarbitol;
- less than about 250 mg daily every 4-7 days of Methsuxamide;
- less than about 600 mg/day of Oxcarbazepine;
- less than about 150 mg/day of Paramethadione;
- less than about 2 mg/day of Perampanel (Fycompa);
- less than about 500 milligrams three times a day of Phenacemide;
- establish a serum level of less than about 10 μg/mL of Phenobarbital;
- less than about 0.5 g b.i.d of Phensuxamide;
- less than about 100 mg a day of Phenytoin;
- less than about 75 mg 2 times a day of Pregabalin;
- a dose of less than about 10 mg/kg/day of Primidone;
- daily dose of less than about 2100 mg of Progabide;
- less than about 400 mg/day of Rufinamide;
- less than about 250 mg twice a day of Stiripentol;
- less than about 100 mg/day of Sulthiame;
- less than about 4 mg/day of Tiagabine;
- less than about 25 mg/day of Topiramate;
- less than about 900 mg/day of Tremethadione;
- less than about 10 mg/kg of Valproate;
- less than about 50 mg/kg/day of Vigabatrin and, less than about 100 mg once a day of Zonisamide.
Dependencies are inferred from the claim text.