Aromatic farnesyl compound and application thereof
AssigneeInstitute of Microbiology, Chinese Academy of Sciences
InventorsHongwei Liu, Kai Wang, Li Bao, Junjie Han
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Abstract
Aromatic farnesyl compound and application of a pharmaceutical salt thereof as an inhibitor of α-glucosidase, dipeptidyl peptidase-4, aldose reductase, protein tyrosine phosphatase-1B or HMG-CoA reductase, or use thereof in preparing medicine and functional healthcare products having a liver protective function and/or for treating and/or preventing type II diabetes, diabetic retinopathy, diabetic foot disease, and hyperlipidemia.
Claims16
An aromatic farnesyl compound of formula (I) or pharmaceutically-acceptable salt thereof:
- wherein, R1 is selected from H, C1-C5 alkyl group —NO2, F, Cl, Br, ester group, and acylamino group the number of R1 is 1, 2 or 3;
- configuration of 1′ is selected from R type and S type;
- R2 is H;
- X is O;
- the bond between 2′ and 3′ is a double bond;
- n=1, 2 or 3;
- and R3 is CH3.
A compound or its pharmaceutically-acceptable salt selected from the group consisting of:
Dependencies are inferred from the claim text.