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US 10,441,559 B2Granted
Method of treating neuropathic pain with a synergistic pharmaceutical composition comprising palmitoylethanolamide and L-acetylcarnitine
AssigneeEpitech Corporation, Ltd.
InventorsFrancesco Della Valle, Maria Federica Della Valle
Life of this patent
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Abstract
A method of controlling the inflammatory and/or neuropatic pain of various origins by administering a pharmaceutical composition containing palmitoylethanolamide, to a human or animal patient. In particular, the present invention relates to the administration of a pharmaceutical composition comprising palmitoylethanolamide (PEA) and L-acetylcarnitine (LAC), optionally in addition with an antioxidant compound, such as a polyphenol, alpha-lipoic acid, or L-acetylcysteine to a patient.
Claims16
A method of treating neuropathic pain, comprising:
- administering to a patient a synergistic pharmaceutical daily dosage form comprising:
- palmitoylethanolamide (PEA), and
- L-acetylcarnitine (LAC) in a finely pulverized form;
- and
- the pharmaceutical daily dosage form is for oral or buccal use, and palmitoylethanolamide (PEA) and L-acetylcarnitine (LAC) are contained in the daily dosage form in doses not exceeding 5 mg/kg of the palmitoylethanolamide (PEA) and not exceeding 10 mg/kg of L-acetylcarnitine (LAC);
- wherein the pharmaceutical daily dosage form has palmitoylethanolamide in a weight percentage between 20 and 35%, L-acetylcarnitine in a weight percentage between 20 and 55% and one or more compounds with antioxidant activity in a total weight percentage ranging between 0 and 20%, and
- a combination of the palmitoylethanolamide, the L-acetylcarnitine and the one or more compounds with antioxidant activity does not exceed a weight percent of 100%.
4 more elements
A method of treating neuropathic pain, comprising:
- administering to a patient a dosage tablet, a capsule, or a liquid form of a synergistic pharmaceutical composition, wherein each dosage tablet, capsule, or liquid form of the pharmaceutical composition comprises:
- an active dosage of palmitoylethanolamide in an amount not to exceed 5 mg/kg;
- an active dosage of L-acetylcarnitine in an amount not to exceed 10 mg/kg;
- and
- an active dosage of one or more compounds with an antioxidant activity in an amount not to exceed 0.5 mg/kg such that each dosage tablet, capsule, or liquid form of the synergistic pharmaceutical composition has palmitoylethanolamide in weight percentages ranging between 20 and 35%, L-acetylcarnitine in weight percentages between 20 and 55%, and the one or more compounds with the antioxidant activity in total weight percentages not to exceed 20%,
- wherein the combination of palmitoylethanolamide, L-acetylcarnitine and the one or more compounds with the antioxidant activity does not exceed a weight percent of 100% and a combined amount of palmitoylethanolamide (PEA) and L-acetylcarnitine (LAC) does not exceed about 1 g per each dosage tablet, capsule, or liquid form of the pharmaceutical composition.
3 more elements
Dependencies are inferred from the claim text.