Back to results
US 10,441,530 B2Granted
Skin penetration enhancing systems for polar drugs
AssigneeAmDerma Pharmaceuticals, LLC
InventorsDavid W. Osborne, Pramod P. Sarpotdar, Arturo J. Angel, Inigo Saenz de Tejada Gorman, Pedro Cuevas Sànchez
Life of this patent
Estimating the term…
Abstract
The invention relates to pharmaceutical compositions and related methods for the topical administration of polar drugs. In a particular embodiment, the invention relates to a pharmaceutical composition comprising an active pharmaceutical agent that is a polar drug, such as potassium 2,5-dihydroxybenzenesulfonate, at least one occlusive agent, and at least one stabilizer.
Claims7
A topical pharmaceutical skin penetration enhancing system, comprising a water-in-oil emulsion that comprises:
- (a) about 5 to about 10% by weight of potassium 2,5-dihydroxybenzenesulfonate (potassium dobesilate);
- (b) about 50 to about 75% by weight of at least one occlusive agent selected from white petrolatum, mineral oil, and mixtures thereof;
- (c) about 0.1 to about 5% by weight of at least one surfactant selected from steareth-2 (Brij 72), steareth-21 (Brij 721), and mixtures thereof;
- (d) about 0.1 to about 10% by weight of a stiffening agent selected from stearyl alcohol, cetyl alcohol, and mixtures thereof;
- (e) about 0.01 to about 10% by weight of a pH adjuster selected from acetic acid solution, sodium acetate, and mixtures thereof;
- and
- about 0.1 to less than about 22% by weight water.
4 more elements
Dependencies are inferred from the claim text.