Biomedical patch and delivery system

A kit for repairing a dural defect, comprising:

• a sterile easily opened packet containing a plurality of biodegradable patches configured to repair a dural defect for a range of expected patients undergoing a surgical procedure, wherein the plurality of biodegradable patches are of a same shape and varying sizes, such that at least one of the plurality of biodegradable patches comprises a size sufficiently large to cover the dural defect and enable a water-tight seal of the dural defect for one of the range of expected patients, wherein each of the plurality of biodegradable patches comprises a wholly synthetic dural substitute material, wherein each of the plurality of biodegradable patches comprises a plurality of creases, wherein the plurality of creases spans a diameter of each of the plurality of biodegradable patches and intersects at an internal point spaced from an outer perimeter on each of the plurality of biodegradable patches, wherein the plurality of creases are adapted to allow each of the plurality of biodegradable patches to be substantially flattened, wherein at least two or more of the plurality of biodegradable patches comprises a different biodegrade time wherein a periphery of a top surface of the at least two or more of the plurality of biodegradable patches comprises an adhesive for adhering the top surface of the flexible patch to the inner surface of the tissue surrounding the dural defect, and wherein the at least two or more of the plurality of biodegradable patches comprise a first biodegrade time, and the adhesive of the at least two or more of the plurality of biodegradable patches comprises a second biodegrade time, wherein the second biodegrade time is longer than the first biodegrade time.

A repair matrix for repairing a tissue defect, comprising:

• a flexible patch, the flexible patch comprising a wholly synthetic dural substitute material formed by electrospinning that facilitates tissue growth, wherein the flexible patch in a first state is configured to be compressed and sized to facilitate implantation of the flexible patch to an inner surface of tissue surrounding the tissue defect, and the flexible patch in a second state is configured to be expanded such that the flexible patch substantially conforms to a curvature of the tissue surrounding the tissue defect,
• wherein the flexible patch in the first state comprises a distal end and a proximate end, wherein the distal end is configured to be inserted at least partially into the tissue defect before the proximate end,
• wherein the distal end of the flexible patch in the first state corresponds to an outer perimeter of the flexible patch in the second state, and wherein the proximate end of the flexible patch in the first state corresponds to a portion of the flexible patch spaced from the outer perimeter of the flexible patch in the second state,
• wherein the flexible patch in the second state comprises a top surface and a bottom surface, wherein the top surface faces outward when the flexible patch is in the first state, and wherein the bottom surface faces inward when the flexible patch is in the first state,
• wherein a periphery of the top surface comprises an adhesive for adhering the top surface of the flexible patch to the inner surface of the tissue surrounding the tissue defect,
• wherein the flexible patch comprises a first biodegrade time, and the adhesive comprises a second biodegrade time, wherein the second biodegrade time is longer than the first biodegrade time, and
• wherein the flexible patch comprises a plurality of creases, wherein the plurality of creases spans a diameter of the flexible patch and intersects at the proximate end, wherein the plurality of creases are adapted to allow the flexible patch to be substantially flattened when in the second state.