Multi-site body fluid sampling and analysis cartridge

An arrangement comprising:

• a housing comprising a plurality of chambers;
• a plurality of sampling and analysis sites, each of the plurality of sampling and analysis sites contained within a respective chamber of the housing and comprising:
• a skin-penetration member having a first end configured to pierce skin, wherein the skin-penetration member comprises an inner lumen in communication with the first end;
• an actuator configured to drive the skin penetration member;
• and
• an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member;
• and
• at least one seal configured to protect the skin-penetration member, actuator, and analyte quantification member from contamination, wherein each chamber is enclosed and completely sealed.