Methods comprising a biocidal polyamine

A method for dispersing or killing a biofilm on a subject, the method comprising a step of topically, orally, transmucosally, vaginally, or rectally administering an anti-biofilm composition to a surface of the subject, thereby effectively dispersing or killing the biofilm;

• wherein the anti-biofilm composition comprises
• (i) a pharmaceutically acceptable carrier;
• and
• (ii) a therapeutically effective amount of a biocidal polyamine compound;
• wherein the biocidal polyamine compound is selected from the group consisting of:
• and a salt thereof;
• wherein:
• each Ra is independently a group of Formula II:
• each of the An members is independently selected from the group consisting of CRa and CR5;
• or, alternatively, a pair of adjacent An members join to form a cycloalkyl, aryl, heterocyclyl, or heterocycloaryl ring;
• wherein at least one An member and at most three An members are independently selected CRa,
• each R1a and R1b is a member independently selected from the group consisting of hydrogen, fluoro, alkyl, and fluoroalkyl;
• each R2a, R2b, R2c, and R2d is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl;
• alternatively, a pair of R2n members from the Ra group independently selected from the group R2a and R2b, and R2c and R2d join to form a ring independently selected from the group consisting of spirocycloalkyl and spiroheterocycyl;
• or, alternatively, the R2a and the R2c from the Ra group join to form a ring independently selected from the group consisting of cycloalkyl and heterocycyl;
• each Rm is a member independently selected from the group consisting of —CR2aR2b—, —CR2cR2d—, —C(R2a)=(R2b)—, —CC— and —C(R2a)(R2b)-L2-C(R2c)(R2d)—;
• m is 1;
• each L1 and L2 is a member independently selected from the group consisting of a bond, —O—, —C(O)O—, —NR4—, —NR4C(O)—, and C(O)NR4—;
• each R3 is a member independently selected from the group consisting of —Z1—Y1—R4 and —Z1—Y1—Y2—R4;
• each R4 is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, and heteroarylalkyl;
• or, alternatively, for a —N(R4)2 group, one of the two R4 in the group is a member selected from the group consisting of —(CO)OR6a—, (CO)N(R6a)(R6b), and —C(NR6a)N(R6b)(R6c);
• each R5 is a member independently selected from the group consisting of hydrogen, alkyl, hydroxyl, alkoxy, alkylamino, alkenyl, alkynyl, aryl, aryloxy, arylamino, cycloalkyl, cycloalkoxy, cycloalkylamino, heterocyclyl, heterocycyloxy, heterocycylamino, halo, haloalkyl, fluoroalkyloxy, heteroaryl, heteroaryloxy, heteroarylamino, arylalkyl, arylalkyloxy, arylalkylamino, heteroarylalkyl, heteroarylalkyloxy, heteroarylalkylamino;
• hydroxyalkyl, aminoalkyl, and alkylaminoalkyl;
• each Y1 and Y2 is an independently selected group of Formula IA:
• each Z1 and Z2 is an independently selected NR4;
• and
• each R6a, R6b, and R6c is a member independently selected from the group consisting of hydrogen, alkyl, fluoroalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, cycloalkyl, and heteroarylalkyl;
• or, alternatively, two R6n members R6a and R6b or R6a and R6c form a heterocycyl ring;
• wherein the biocidal polyamine compound comprises at least two primary or secondary amino groups.