Method for enhancing electrospray
AssigneeAgilent Technologies, Inc.
InventorsSteven M. Fischer, Justin R. Cross
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Abstract
Provided herein, among other things, is a method of ionizing a first stream of liquid by an electrospray ion source having a nebulizer, wherein the first stream of liquid may comprise an analyte. In some embodiments, the method may comprise: a) providing the first stream of liquid to the nebulizer; b) adding a second stream of liquid to the first stream of liquid, wherein the second stream of liquid comprises a co-solvent that has a relatively high boiling point and an enhancement solvent that a relatively high boiling; and c) nebulizing and ionizing the resulting liquid.
Claims20
A method of ionizing a first stream of liquid by an electrospray ion source having a nebulizer, wherein the first stream of liquid may comprise an analyte, the method comprising:
- a) providing the first stream of liquid to the nebulizer;
- b) adding a second stream of liquid to the first stream of liquid in the nebulizer, at an input end of the nebulizer, or upstream of the nebulizer;
- and wherein the second stream of liquid comprises a mixture of a co-solvent and an enhancement solvent, the co-solvent having a boiling point between 4° C. and 110° C., and the enhancement solvent having a boiling point between 150° C. and 300° C.;
- and
- c) nebulizing and ionizing the resulting liquid,
- wherein, if the enhancement solvent is DMSO, then the electrospray ion source is run in negative ion mode.
Dependencies are inferred from the claim text.