Methods of resolving artifacts in Hadamard-transformed data
AssigneeBattelle Memorial Institute
InventorsKevin L. Crowell, Spencer A. Prost
Life of this patent
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Abstract
A method of validating data produced from a multiplexing process on an analytical instrument is disclosed. In one embodiment, the method includes using a pseudorandom sequence to encode a multiplexed segment of data; applying Hadamard transform to generate a demultiplexed segment of the data; aligning the pseudorandom sequence to the multiplexed data; and calculating a score for at least one positive value in the demultiplexed segment to find a valid demultiplexed value.
Claims21
A method of validating data produced from a multiplexing process on an analytical instrument comprising a detector, the method comprising:
- by a computer:
- receiving intensity data generated by the detector in response to the multiplexing process in the form of multiplexed data, the multiplexing process being performed according to a pseudorandom sequence;
- applying Hadamard transform to the intensity data to form demultiplexed data;
- aligning the pseudorandom sequence to the multiplexed data, a first “1” in the pseudorandom sequence being aligned to a positive value in the multiplexed data;
- and
- using multiplexed data having a corresponding “1” in the pseudorandom sequence to increase a signal to noise ratio of the intensity data.
A method of validating data produced from a multiplexing process on an analytical instrument comprising:
- with a detector coupled to the analytical instrument, generating intensity data in the form of multiplexed data;
- and
- by a computer:
- receiving intensity data generated by the detector in the form of multiplexed data, the multiplexing process being performed according to a pseudorandom sequence;
- applying Hadamard transform to the intensity data to form demultiplexed data;
- aligning the multiplexed and demultiplexed data to determine positive or negative values;
- aligning the pseudorandom sequence to at least one of the determined positive values in the multiplexed data or the demultiplexed data;
- and
- using multiplexed data having a corresponding “1” in the pseudorandom sequence to increase a signal to noise ratio of the intensity data.
An analytical instrument, comprising:
- a gate;
- a detector;
- a processor situated to receive data generated by the detector;
- and
- one or more computer-readable storage devices or memory storing computer-executable instructions that when executed by the processor, cause the processor to perform a method, the method comprising:
- receiving intensity data generated by the detector in the form of multiplexed data, the multiplexing process being performed according to a pseudorandom sequence;
- applying Hadamard transform to the intensity data to form demultiplexed data;
- aligning the multiplexed and demultiplexed data to determine positive or negative values;
- aligning the pseudorandom sequence to the multiplexed data, wherein a first ‘1’ in the pseudorandom sequence is aligned to a positive value in the multiplexed data;
- and
- using multiplexed data having a corresponding “1” to increase a signal to noise ratio of the intensity data.
An analytical instrument, comprising:
- a gate;
- a detector;
- a processor situated to receive multiplexed intensity data generated by the detector, the multiplexing process being performed according to a pseudorandom sequence;
- and
- one or more computer-readable storage devices or memory storing computer-executable instructions that when executed by the processor, cause the processor to perform a method, the method comprising:
- a step for applying Hadamard transform to the intensity data to form demultiplexed data;
- a step for aligning the multiplexed and demultiplexed data to determine positive or negative values;
- a step for aligning the pseudorandom sequence to the multiplexed data;
- and
- a step for using multiplexed data having a corresponding “1”.
Dependencies are inferred from the claim text.