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US 10,371,865 B2Granted
Silicone hydrogels comprising polyamides
AssigneeJohnson & Johnson Vision Care, Inc.
InventorsAzaam Alli, Alexander Guzman
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Abstract
Described are silicone hydrogels that are more biocompatible than current ocular materials. The silicone hydrogels are formed from a reactive monomer mixture comprising: a mixture of hydroxyl substituted silicone containing components, at least one polyamide; and at least one hydrophilic monomer. The silicone hydrogels also display a desirable balance of properties, including clarity, oxygen permeability, wettability and desirable protein uptake.
Claims55
A silicone hydrogel formed from a reactive monomer mixture comprising:
- a) between about 1 and about 15 wt % at least one polyamide;
- b) at least one first mono-functional, hydroxyl substituted poly(disubstituted siloxane) having 4 to 8 siloxane repeating units;
- c) at least one second hydroxyl substituted poly(disubstituted siloxane) that is a mono-functional hydroxyl substituted poly(disubstituted siloxane)s having 10 to 200 siloxane repeating units;
- d) about 5 to about 35 wt % of at least one hydrophilic monomer;
- wherein the first hydroxyl substituted poly(disubstituted siloxane) and the second mono-functional hydroxyl substituted poly(disubstituted siloxane) are present in concentrations to provide a ratio of wt % of all first hydroxyl substituted poly(disubstituted siloxane) to wt % of all second hydroxyl substituted poly(disubstituted siloxane)s of 0.4-1.3.
2 more elements
A silicone hydrogel formed from a reactive monomer mixture comprising:
- a) between about 1 and about 15 wt % at least one polyamide;
- b) at least one hydroxyl silicone-containing monomer;
- c) at least one hydroxyl substituted poly(disubstituted siloxane) selected from the group consisting of monofunctional poly(disubstituted siloxane) having 4 to 8 siloxane repeating units, and monofunctional hydroxyl substituted poly(disubstituted siloxane)s having 10 to 200 siloxane repeating units, and mixtures thereof;
- d) about 5 to about 25 wt % at least one hydrophilic monomer;
- wherein the first hydroxyl substituted poly(disubstituted siloxane) and the second monofunctional hydroxyl substituted poly(disubstituted siloxane) are present in concentrations to provide a ratio of wt % of all first hydroxyl substituted, linear poly(disubstituted siloxane) to wt % of all one second hydroxyl substituted poly(disubstituted siloxane)s of 0.4-1.3.
2 more elements
Dependencies are inferred from the claim text.