Method for two field nuclear magnetic resonance measurements

A method for carrying out two-field nuclear magnetic resonance (=2FNMR) measurements on a sample, the method comprising the steps of:

• a) preparing the sample during a preparation period in a first working volume of a first magnetic field with a first field strength and having a homogeneity better than 0.01 ppm;
• b) transferring, during a first transfer period, the sample to a second working volume with a second magnetic field having a homogeneity of 100 ppm or better or in a range between 2 ppm and 100 ppm, and having a second field strength of 0.05 Tesla or larger or of 0.1 Tesla or larger, wherein the first field strength is at least 2 Tesla larger than the second field strength;
• c) manipulating, during a manipulation period, the sample at the second working volume by applying a sequence of radio-frequency (=RF) and/or field gradient pulses, wherein the sequence is insensitive to or minimizes effects of an inhomogeneity of the second magnetic field in the second working volume;
• d) transferring the sample back to the first working volume during a second transfer period;
• and
• e) detecting an NMR signal of the sample in the first working volume.