Biomarker of renal dysfunction

A method of treating a subject at increased risk of renal dysfunction induced by a planned physical trauma, wherein the method comprises the step of:

• a) obtaining a urine sample from a subject prior to the planned physical trauma, wherein the planned physical trauma is elective surgery;
• b) detecting the anti-inflammatory cytokine present in the urine sample obtained in step a), wherein the anti-inflammatory cytokine is selected from the group consisting of IL-1ra, TNFsr1 and TNFsr2 and any combination thereof;
• c) detecting the anti-inflammatory cytokine in a pre-event normal control, wherein the pre-event normal control is a normal level of anti-inflammatory cytokine presented by a control group or a predetermined normal cytokine level;
• d) calculating the level of anti-inflammatory cytokine detected in step b) relative to the level of anti-inflammatory cytokine detected in step c);
• e) determining that the subject has a greater than normal chance of developing renal dysfunction induced by planned physical trauma when the level of anti-inflammatory cytokine determined in step b) is lower than the level of anti-inflammatory cytokine detected in step c);
• and
• f) applying therapeutic measures to treat or obviate renal dysfunction to the subject, wherein the therapeutic measures are selected from maintaining a supra-normal blood pressure;
• ensuring adequate tissue oxygen delivery;
• administration of steroids;
• renal replacement therapy;
• dialysis;
• or any combination thereof.