Systems and methods for high accuracy analyte measurement

A method for determining a concentration of an analyte in a sample, the method comprising:

• introducing a sample including an analyte to an electrochemical sensor having one or more adhesive layers, the electrochemical sensor including a reaction chamber comprising two electrodes in a spaced apart configuration;
• and
• reacting the analyte to cause a physical transformation of the analyte between the two electrodes;
• determining a concentration of the analyte that is corrected for a physical property of the electrochemical sensor using a correction factor that is based on a capacitance of the electrochemical sensor, wherein the capacitance is a function of a slow flow of the one or more adhesive layers into the reaction chamber;
• wherein the method achieves an accuracy standard of at least ±10% for analyte concentrations above an analyte concentration threshold or at least ±10 mg/dL below an analyte concentration threshold, such that at least 95% of a series of analyte concentration evaluations yield an analyte concentration value that is accurate to within 10% of a reference analyte measurement.

A method for measuring a corrected analyte concentration in a sample, the method comprising:

• detecting a presence of the sample in an electrochemical sensor, the
• electrochemical sensor comprising two electrodes and one or more adhesive layers;
• reacting an analyte in a reaction chamber to cause a physical transformation of the analyte;
• determining a first analyte concentration in the sample;
• and
• calculating a corrected analyte concentration based on the first analyte concentration and one or more correction factors, the one or more correction factors including a correction factor calculated in view of a physical property of the electrochemical sensor, wherein the one or more correction factors includes a correction factor based on a measured capacitance of the electrochemical sensor, the measured capacitance being a function of a slow flow of the one or more adhesive layers into the reaction chamber.

An electrochemical system, comprising:

• an electrochemical sensor including electrical contacts configured to mate with a test meter, the electrochemical sensor comprising:
• a reaction chamber inclusing a first electrode and a second electrode in a spaced apart relationship,
• one or more adhesive layers, and
• a reagent;
• and
• the test meter including a processor configured to receive current data from the electrochemical sensor upon application of voltages to the electrochemical sensor, and further configured to determine a corrected analyte concentration based on a correction factor to correct for a physical property of the electrochemical sensor, wherein the correction factor is based on a measured capacitance of the electrochemical sensor, the measured capacitance being a function of a slow flow of the one or more adhesive layers into the reaction chamber, and one or more of a fill time of a sample, a temperature of the sample, a temperature of the electrochemical sensor, and glucose reaction kinetics.