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US 10,371,638 B2Granted
Fluorescent microscope
AssigneeIndiana University Research and Technology Corporation
InventorHany Osman
Life of this patent
Estimating the term…
Abstract
The present disclosure provides a method and system including a non-confocal microscope with an attached imaging fiber optic for direct and real time visualization of mammalian microscopic structures for diagnostic and therapeutic uses.
Claims17
An adapter for a microscope comprising:
- a fiber-optic connecter;
- a lateral adjustment connector in mechanical communication with the fiber-optic connecter, wherein the lateral adjustment connecter is configured to adjust the fiber-optic connecter laterally;
- a vertical adapter configured to move the fiber-optic connecter along an image acquisition axis;
- and
- wherein the microscope comprises a tube lens and an image acquisition device;
- and
- has a ratio X that is between 0.5 and 1.5, where
- X
- =
- Distance
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- from
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- a
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- proximal
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- end
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- of
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- the
- fiber
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- -
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- optic
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- and
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- the
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- tube
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- lens
- Distance
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- from
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- the
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- tube
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- lens
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- and
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- image
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- acquisition
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- device
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69 more elements
A system comprising:
- a plurality of fluorescent microscopes, wherein a first fluorescent microscope comprises a first fiber-optic adapter connected to a first fiber-optic;
- and a second fluorescent microscope comprises a second fiber-optic adapter connected to a second fiber-optic, wherein
- the first fiber-optic and the second fiber-optic are in mechanical communication;
- and
- wherein the at least one fluorescent microscope of the plurality of fluorescent microscopes comprises a tube lens and an image acquisition device;
- and
- has a ratio X that is between 0.5 and 1.5, where
- X
- =
- Distance
-
-
- from
-
-
- a
-
-
- proximal
-
-
- end
-
-
- of
-
-
- the
- fiber
-
- -
-
- optic
-
-
- and
-
-
- the
-
-
- tube
-
-
- lens
- Distance
-
-
- from
-
-
- the
-
-
- tube
-
-
- lens
-
-
- and
- the
-
-
- image
-
-
- acquisition
-
-
- device
- .
69 more elements
A method for evaluating a specimen, comprising:
- routing a first light having a wavelength that causes a fluorescent dye applied to a specimen to fluoresce through a microscope having an imaging fiber optic coupled to a magnifying objective and having a distal tip disposed adjacent the specimen;
- wherein the at least one fluorescent microscope of the plurality of fluorescent microscopes comprises a tube lens and an image acquisition device;
- and
- has a ratio X that is between 0.5 and 1.5, where
- X
- =
- Distance
-
-
- from
-
-
- a
-
-
- proximal
-
-
- end
-
-
- of
-
-
- the
-
-
- fiber
- -
- optic
-
-
- and
-
-
- the
-
-
- tube
-
-
- lens
- Distance
-
-
- from
-
-
- the
-
-
- tube
-
-
- lens
-
-
- and
-
-
- the
-
-
- image
-
-
- acquisition
-
- device
- ;
- routing a second light reflected from the specimen through the microscope to the magnifying objective;
- and
- generating an image of the specimen using an image acquisition device, wherein the microscope comprises an adapter, wherein the adapter comprises:
- a fiber-optic connecter,
- a lateral adjustment connector in mechanical communication with the fiber-optic connecter, wherein the lateral adjustment connecter is configured to adjust the fiber-optic connecter laterally, and
- a vertical adapter configured to move the fiber-optic connecter along an image acquisition axis.
73 more elements
Dependencies are inferred from the claim text.