Back to results
US 10,370,724 B2Granted
PRKC fusions
AssigneeBlueprint Medicines Corporation
InventorsNicolas Stransky, Joseph L. Kim
Life of this patent
Estimating the term…
Abstract
The invention provides PRKC gene fusions, PRKC fusion proteins, and fragments of those genes and polypeptides. The invention further provides methods of diagnosing and treating diseases or disorders associated with PRKC fusions, such as conditions mediated by aberrant PRKC expression or activity, or overexpression of PRKC.
Claims7
A method for detecting in a patient an IGF2BP3:PRKCA fusion, said method comprising:
- a) contacting a biological sample from the patient with an oligonucleotide that hybridizes to or amplifies the IGF2BP3:PRKCA fusion of SEQ ID NO:
- 1 or a portion thereof comprising a fusion junction;
- and
- b) detecting (i) binding between the IGF2BP3:PRKCA fusion and the oligonucleotide or (ii) detecting amplification of the IGF2BP3:PRKCA fusion.
1 more element
Dependencies are inferred from the claim text.