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US 10,370,723 B2Granted
TERT fusions
AssigneeBlueprint Medicines Corporation
InventorNicolas Stransky
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Abstract
The invention provides TERT gene fusions, TERT fusion proteins, and fragments of those genes and polypeptides. The invention further provides methods of diagnosing diseases or disorders associated with TERT fusions, such as conditions mediated by aberrant TERT expression or activity, or overexpression of TERT.
Claims5
A method for detecting in a patient a TRIO:TERT fusion, said method comprising:
- a) contacting a biological sample from the patient with an oligonucleotide that hybridizes to or amplifies the TRIO:TERT fusion of SEQ ID NO:
- 1 or a portion thereof comprising a fusion junction;
- and
- b) detecting (i) binding between the TRIO:TERT fusion and the oligonucleotide or (ii) detecting amplification of the TRIO:TERT fusion.
1 more element
Dependencies are inferred from the claim text.