Method of determining risk of 5-fluorouracil toxicity
AssigneeOxford University Innovation Limited
InventorsDavid Kerr, Ian Tomlinson, Dan Rosmarin, Claire Palles
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Abstract
The invention provides an assay useful in predicting risk of 5-fluorouracil (FU) toxicity in a subject. The subject may be screened for the presence of at least one TYMS polymorphism and/or at least one DPYD polymorphism. Suitable TYMS and DPYD polymorphisms are provided. The presence of one or more of the polymorphisms indicates an increased risk of developing FU toxicity; a negative result may indicate a decreased risk of developing FU toxicity.
Claims9
A method, comprising isolating a sample and detecting in the sample by assay (a) a thymidylate synthase (TYMS) polymorphisms rs2612091 and (b) at least one dihydropyrimidine dehydrogenase (DPYD) polymorphism selected from the group consisting of:
- rs3918290, rs67376798, rs12132152, rs12022243 and substitution of guanine for adenine at coding DNA position 1651 (C.G1651A).
Dependencies are inferred from the claim text.