US 10,370,717 B2Granted

Methods for the measurement of post-traumatic stress disorder microRNA markers

AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

InventorsRadha K. Maheshwari, Nagaraja S. Balakathiresan, Manish Bhomia, Raghavendar Chandran

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Abstract

The present invention provides for methods of measuring levels of micro RNAs for the diagnosis, treatment and/or monitoring the progression of post-traumatic stress disorder (PTSD) or traumatic brain injury (TBI) in a subject having or suspected of having PTSD and/or TBI. The methods, in general comprise measuring levels of at least one of miR-142-5p, miR-19b, miR-1928, miR-223-3p, miR-322*, miR-324, miR-421-3p, miR-463* and miR-674* is a sample from a subject suffering from or suspected of having PTSD and/or TBI.

Claims7

Dependent claims

A process for administering a therapeutic agent for treating post-traumatic stress disorder (PTSD), the process comprising:

measuring levels of miR-19b-3p, miR-223-3p and miR-221-3p micro RNA in a biological sample obtained at a first time point from a subject suspected of suffering from PTSD, comprising hybridizing agents that specifically hybridize to each of the micro RNA, amplifying each of the micro RNA and sequencing the micro RNA to confirm the identity of each of the micro RNA and quantifying the identified RNA, and
administering a therapeutic for the treatment of PTSD based on the measurements of the micro RNA.

Dependencies are inferred from the claim text.

Facts

Application: 15/306,178Filed 21 Apr 2015 · us provisional application
Priority: 22 Apr 2014
Published: US 2017/0044613 A116 Feb 2017
Granted: 6 Aug 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification4 codes

C12Q 1/6883
Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes: for diseases caused by alterations of genetic material
C12Q 2600/158
Oligonucleotides characterized by their use: expression markers
C12Q 2600/178
Oligonucleotides characterized by their use: mirna, sirna or ncrna
C12Q
Measuring or testing processes involving enzymes, nucleic acids or microorganisms

Family

Application61/982,651Us provisional application · filed 22 Apr 2014
US 2017/0044613 A1Pre-grant publication · published 16 Feb 2017
US 10,370,717 B2This patent

From the US filing history. Foreign family members aren’t listed.

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