Methods for identifying, diagnosing, and predicting survival of lymphomas

A method of treating a subject suffering from diffuse large B cell lymphoma (DLBCL), the method comprising:

• (1) determining a first survival predictor score for the subject comprising the steps of a) through f:
• a) isolating gene expression product from a biopsy sample from the subject;
• b) obtaining gene expression data from the isolated gene expression product by detecting expression levels for genes in an ABC DLBCL high gene expression signature, a lymph node gene expression signature, and an MHC class II gene expression signature;
• c) obtaining an average gene expression level for the genes in the ABC DLBCL high gene expression signature to thereby obtain an ABC DLBCL high gene expression signature value;
• d) obtaining an average gene expression level for the genes in the lymph node gene expression signature to thereby obtain a lymph node gene expression signature value;
• e) obtaining an average gene expression level for the genes in the MHC class II gene expression signature to thereby obtain an MHC class II gene expression signature value;
• and
• f) calculating a survival predictor score using an equation:
• [0.586*(ABC DLBCL high gene expression signature value)] - [0.468*(lymph node gene expression signature value)] - [0.336*(MHC class II gene expression signature)];
• wherein a higher survival predictor score is associated with worse survival;
• (2) determining a second survival predictor score for the subject comprising the steps of a) through f) of (1);
• (3) comparing the first and second survival predictor scores of (1) and (2);
• (4) determining the subject has a poor prognosis by determining the second survival predictor score is higher than the first survival predictor score;
• and
• (5) treating the subject.