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US 10,370,712 B2Granted
Signatures of radiation response
AssigneeDuke University
InventorsJohn P. Chute, Joseph R. Nevins, Joseph Lucas, Holly K. Dressman
Life of this patent
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Abstract
The present invention relates, in general, to gene expression profiles, and in particular, to a gene expression profile of an environmental exposure, ionizing radiation. The invention further relates to methods of screening patients for radiation exposure based on gene expression profiling and to kits suitable for use in such methods.
Claims6
A method comprising:
- i) obtaining a blood sample from a human,
- ii) isolating mononuclear cells from said blood sample,
- iii) extracting RNA from said mononuclear cells,
- iv) analyzing RNA in said blood sample for expression of a gene set consisting of FDXR, ASPA, RFC4, METTL8, RASL12, ASTN2, RASA4, TRIB2, BBC3, RPA1, Gna15, H2AFV, PARP1, CEBPB, CDKN1A, PRIM1, NINJ1, BAX, HIST1H3D, HIST1H2BH, DDB2, BCL11B, FAM134C, and LAPTM5, or a subset thereof comprising at least 5 of said genes and comprising TRIB2, PARP1, and LAPTM5;
- and wherein said blood sample is obtained within 7 days of exposure of said individual to radiation.
2 more elements
A method comprising:
- i) obtaining a blood sample from a human, and
- ii) analyzing RNA in the blood sample for expression of a gene set consisting of FDXR, ASPA, RFC4, METTL8, RASL12, ASTN2, RASA4, TRIB2, BBC3, RPA1, Gna15, H2AFV, PARP1, CEBPB, CDKN1A, PRIM1, NINJ1, BAX, HIST1H3D, HIST1H2BH, DDB2, BCL11B, FAM134C, and LAPTM5, or a subset thereof comprising at least 5 of said genes and comprising TRIB2, PARP1, and LAPTM5;
- and wherein said blood sample is obtained within 7 days of exposure of said individual to radiation.
Dependencies are inferred from the claim text.