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US 10,370,689 B2Granted
Production of lysergic acid by genetic modification of a fungus
AssigneeWest Virginia University
InventorsDaniel G. Panaccione, Sarah L. Robinson
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AssigneeWest Virginia University
InventorsDaniel G. Panaccione, Sarah L. Robinson
Estimating the term…
The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) or any fungus having a pathway similar to Aspergillus fumigatus and expressing one or more genes of the ergot alkaloid biosynthesis pathway from one or more fungus selected from the group consisting of Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1); Claviceps species; Claviceps africana (C. africana); Claviceps gigantea (C. gigantea); Epichloë coenophiala and Periglandula species, wherein gene easA or gene easM is inactivated in said A. fumigatus or said fungus having a pathway similar to Aspergillus fumigatus, is provided.
A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) and expressing one or more genes of the ergot alkaloid biosynthesis pathways from Epichloë festucae var. lolii×Epichloë typhina isolate Lp1 (E. sp. Lp1), and optionally one or more fungus selected from the group consisting of:
A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) and expressing one or more genes of the ergot alkaloid biosynthesis pathways from Claviceps africana (C. africana), and optionally one or more fungus selected from the group consisting of:
A strain of fungus comprising Aspergillus fumigatus (A. fumigatus) and expressing one or more genes of the ergot alkaloid biosynthesis pathways from Claviceps gigantea (C. gigantean), and optionally one or more fungus selected from the group consisting of:
A strain of fungus comprising SEQ ID NO:7.
Dependencies are inferred from the claim text.