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US 10,370,669 B2Granted
Nucleic acid compounds for binding growth differentiation factor 8
AssigneeSomaLogic, Inc.
InventorsUrs Ochsner, Louis Green, Nebojsa Janjic
Life of this patent
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Abstract
Described herein are aptamers capable of binding to growth differentiation factor 8 (GDF8) protein; compositions comprising a GDF8 binding aptamer; and methods of making and using the same.
Claims23
An aptamer that binds GDF8, wherein the aptamer comprises the sequence:
- 5′-GWWR1CnR2ZGnGWCnX2CWnWWX1AnR1CnX1KWnAGX2nWCX1ZD-3′ (SEQ ID NO:
- 1),
- wherein:
- each W is independently, and for each occurrence, a C-5 modified pyrimidine;
- X1 and X2 are each independently selected from W and C;
- R1 and R2 are each independently selected from G and A;
- each Z is independently selected from A and W;
- K is selected from G and W;
- D is selected from G, A, and W;
- and
- each n is independently selected from 0 and 1;
- or wherein the aptamer comprises the sequence:
- 5′-X1GWWR1CnR2ZGnGWCnX2CWnWWX1AnR1CnX1KWnAGX2nWCX1ZD-3′ (SEQ ID NO:
- 2),
- wherein:
- each W is independently, and for each occurrence, a C-5 modified pyrimidine;
- X1 and X2 are each independently selected from W and C;
- R1 and R2 are each independently selected from G and A;
- each Z is independently selected from A and W;
- K is selected from G and W;
- D is selected from G, A, and W;
- and
- each n is independently selected from 0 and 1;
- or wherein the aptamer comprises the sequence:
- 5′-GWWR1R2ZGWCnX2CWnWWX1AnR1CnX1KAGWCX1ZD-3′ (SEQ ID NO:
- 49), wherein:
- each W is independently, and for each occurrence, a C-5 modified pyrimidine;
- X1 and X2 are each independently selected from W and C;
- R1 and R2 are each independently selected from G and A;
- each Z is independently selected from A and W;
- K is selected from G and W;
- D is selected from G, A, and W;
- and
- each n is independently selected from 0 and 1;
- or wherein the aptamer comprises the sequence:
- 5′-WGWWAGZGWX2CWWX1AWGAGWCWAD-3′ (SEQ ID NO:
- 3), wherein:
- each W is independently, and for each occurrence, a C-5 modified pyrimidine;
- X1 and X2 are each independently selected from W and C;
- Z is selected from A and W;
- and
- D is selected from G, A, and W;
- or wherein the aptamer comprises the sequence:
- 5′-GWWAGAGWCCWWWAWGAGWCWAG-3′ (SEQ ID NO:
- 4), wherein each W is independently, and for each occurrence, a C-5 modified pyrimidine.
42 more elements
An aptamer that binds GDF 8, wherein the aptamer comprises a sequence selected from SEQ ID NOs:
- 5 to 48.
Dependencies are inferred from the claim text.