Delivery of therapeutic agent
AssigneeCodiak BioSciences, Inc.
InventorsJan Lötvall, Jonas Andrej Nilsson
Life of this patent
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Abstract
A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a DNA sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said inhibitor oligonucleotide from said cell. Nanovesicles produced by the claimed method can be effectively and specifically targeted to e.g. cancer cells to deliver the inhibitor oligonucleotide.
Claims7
An isolated nanovesicle comprising a recombinantly expressed c-Myc inhibitor oligonucleotide, and further comprising a targeting molecule on the surface of the nanovesicle, wherein said targeting molecule is an antibody or fab-fragment thereof, and wherein the nanovesicle is produced by a producer cell recombinantly expressing L-myc.
Dependencies are inferred from the claim text.