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US 10,370,660 B2Granted
Antisense oligonucleotides to treat Dystrophic Epidermolysis Bullosa
AssigneeWings Therapeutics, Inc.
InventorsElisabeth Marlene Haisma, Marko Potman, Gerardus Johannes Platenburg
Life of this patent
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Abstract
An antisense oligonucleotide capable of preventing or reducing exon 80 inclusion into a human COL7A1 mRNA, and methods for preventing or reducing exon 80 inclusion into a human COL7A1 mRNA.
Claims20
An antisense oligonucleotide (AON) capable of preventing or reducing exon 80 inclusion into a human COL7A1 mRNA when the mRNA is produced by splicing from a pre-mRNA in a cell, wherein the AON comprises a nucleotide sequence selected from SEQ ID NOs:
- 8, 25, 26, 31 and 32.
Dependencies are inferred from the claim text.