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US 10,370,656 B2Granted
Nucleic acid functionalized nanoparticles for therapeutic applications
AssigneeNorthwestern University
InventorsChad A. Mirkin, David A. Giljohann, Dwight S. Seferos
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Abstract
Materials and methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle.
Claims16
A method of modulating effectiveness of an anticancer drug comprising the step of:
- administering said anticancer drug concomitantly with an oligonucleotide-functionalized nanoparticle, wherein said oligonucleotide-functionalized nanoparticle comprises an oligonucleotide comprising a sequence that modulates the effectiveness of said anticancer drug, and wherein the nanoparticle does not comprise a targeting agent.
Dependencies are inferred from the claim text.