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AssigneeNational University Corporation Tottori University
InventorsTakafumi Nakamura, Kousuke Horita, Hajime Kurosaki, Motomu Nakatake
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It is an object of the present invention to provide utilization of a UCA1 gene that is a host regulatory factor that enhances replication and/or propagation of a vaccinia virus, in order to effectively carry out cancer virotherapy using the vaccinia virus. The present invention relates to: a method for predicting and evaluating the cancer therapeutic effects of a vaccinia virus, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that a vaccinia virus exhibits cancer therapeutic effects on the patient, when the UCA1 gene has been expressed therein; and a vaccinia virus into which a UCA1 gene has been expressibly introduced.
A method for predicting and evaluating the cancer therapeutic effects of an oncolytic vaccinia virus that replicates in cancer cells, which comprises measuring the expression of a UCA1 gene in the cancer cells of a cancer patient, and then predicting that the oncolytic vaccinia virus exhibits cancer therapeutic effects on the patient, when expression of the UCA1 gene exceeds a determined threshold value.
An oncolytic vaccinia virus that replicates in cancer cells, into which a UCA1 gene has been expressibly introduced, wherein the vaccinia virus is modified to allow the expression of a B5R gene, and wherein the vaccinia virus is an LC16 strain, an LC16mO strain, or an LC16m8 strain.
A pharmaceutical composition kit for cancer therapy, comprising an expression vector into which a UCA1 gene has been expressibly introduced, in combination with an oncolytic vaccinia virus that replicates in cancer cells, wherein the vaccinia virus is modified to allow the expression of a B5R gene, and wherein the vaccinia virus is an LC16 strain, an LC16mO strain, or an LC16m8 strain.
Dependencies are inferred from the claim text.