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US 10,370,645 B2Granted
Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
AssigneesEmory University, Dana-Farber Cancer Institute, Inc., Brigham and Women's Hopsital, President and Fellows of Harvard College
InventorsKevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
Life of this patent
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Abstract
Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
Claims9
An in vitro method of making a population of human pancreatic and duodenal homeobox (PDX1)-positive pancreatic endoderm, comprising:
- a) obtaining a population of human definitive endoderm cells;
- and
- b) contacting the population of human definitive endoderm cells from step (a) with a retinoid, thereby making the population of human PDX1-positive pancreatic endoderm.
Dependencies are inferred from the claim text.